منابع مشابه
DNA microarrays, chromatin, transcription
The DNA microarray-based technique has been developed to semi-quantitatively measure the in vivo global chromatin condensation state at the resolution of a gene. Chromatin was fractionated due to the differential solubility of histone H1-containing and histone H1-free nucleosomes. A set of genes non-randomly distributed between histone H1-free (uncondensed or open) and histone H1-containing (co...
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As outlined in the preceding chapters, an outstanding problem in the field of eukaryotic gene regulation is understanding the biochemical mechanism by which gene-specific activators regulate transcription. In Chapters 11 and 12, we discussed biochemical strategies to dissect how these transcriptional regulators interact with their cognate DNA sequences and enhance transcription from DNA templat...
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some time that PARP-1 is one of the first substrates to used throughout the book are particularly useful. Even be cleaved by caspases during apoptosis. This cleavage though each chapter has a different set of authors, there separates the DNA binding and catalytic domains, ren-is minimal repetition and plenty of cross referencing dering on one hand a protein fragment that can bind DNA throughout...
متن کاملTranscription factor access to chromatin.
The question of how sequence-specific transcription factors access their cognate sites in nucleosomally organized DNA is discussed on the basis of genomic footprinting data and chromatin reconstitution experiments. A classification of factors into two categories is proposed: (i) initiator factors which are able to bind their target sequences within regular nucleosomes and initiate events leadin...
متن کاملTranscription Elongation: TLKing to Chromatin?
Tousled-like kinases (TLKs) have important functions during the cell cycle in eukaryotes. The TLK family was named after its founding member, the product of the TOUSLED gene which is essential for normal development of the plant Arabidopsis thaliana [1]. More recently, these kinases have been implicated in deposition of chromatin following DNA replication. During S phase, nucleosomes must be as...
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ژورنال
عنوان ژورنال: Cell
سال: 2001
ISSN: 0092-8674
DOI: 10.1016/s0092-8674(01)00352-x